Transcription-coupled repair (TCR) represents a specialised subpathway of nucleotide excision repair that accelerates removal of lesions on the transcribed strand of active genes. In bacteria, DNA ...

Red arrows indicate the DNA repair pathways that are known to aid bacterial survival as persisters and gamblers in the presence of fluoroquinolones. Blue color arrow indicates downregulation, while ...

Inside every cell, thousands of molecular signals collide, overlap, and compensate, obscuring the true drivers of gene expression. Scientists have now developed a way to silence that cellular noise, ...

Heme binding to a bacterial transcription factor is critical for hydrogen sulfide (H 2 S) signaling, report researchers from Japan. Heme binding promotes the reaction of H 2 S with the transcription ...

Ribonucleotide reductases (RNR) are indispensable enzymes that convert ribonucleotides to deoxyribonucleotides (dNTPs), the precursors to make up DNA. Because DNA synthesis is fundamental to cell ...

Bacteria possess unique traits with great potential for benefiting society. However, current genetic engineering methods to harness these advantages are limited to a small fraction of bacterial ...

Elizabeth Campbell studies the molecular machinery that all living cells use to read and transcribe their genetic ...