Nature

Single-cell copy number alteration signature analysis reveals masked patterns and potential biomarkers for cancer

Copy number alteration (CNA) is a major type of cancer genome alteration that drives cancer progression. CNA signature analysis can reveal underlying etiology and provide biomarkers for cancer ...
Nature

RCANE: a deep learning algorithm for whole-genome pan-cancer somatic copy number aberration prediction using RNA-seq data

Somatic copy number aberrations (SCNAs) are a hallmark of cancer, involving large-scale genomic alterations that drive tumorigenesis and cancer progression by affecting gene dosage and altering the ...
Medical Xpress

DNA copy-number changes help melanoma develop resistance to immunotherapy, study finds

A study led by UCLA Health Jonsson Comprehensive Cancer Center investigators reveals how melanoma, the deadliest form of skin cancer, evolves to resist immunotherapy and identifies a potential ...
ascopubs.org

Characterization of copy number variations (CNV) patterns and pseudotime trajectories in high-grade serous ovarian cancer (HGSOC).

Neoadjuvant pamiparib in patients with newly diagnosed advanced ovarian cancer: A single-arm, prospective phase II trial. This is an ASCO Meeting Abstract from the 2025 ASCO Annual Meeting I. This ...