During replication, DNA polymerases are positioned on each strand of DNA . Using a microscope slide as an anchor, we tethered DNA to a bead and stretched it with a flow of solution. We tracked how the ...

Hypoxia is common in tumors and is associated with cancer progression and drug resistance, driven, at least in part, by genetic instability. Little is known on how hypoxia affects Translesion DNA ...

Researchers shed new light on G-quadruplexes, a type of secondary DNA structure that has attracted attention as a potential therapeutic target in cancer. Every day, billions of cells in your body ...

Daughter cells vary significantly after stress In addition to real-time measurements under the microscope, the researchers examined various endpoints, such as the strength of different stress signals ...

The use of small molecules as fluorescent DNA markers has been extensively explored since the mid-1960s, revealing limitations in designing selective probes due to the largely missing relationship ...

Every time a cell divides, it must copy its DNA with extraordinary precision. But this process is constantly challenged by DNA damage. Among the most dangerous lesions are DNA interstrand crosslinks ...

Cells are the smallest units of life. But even within the same tissue or organ, they are not all identical. New variations arise continuously during cell proliferation. While genetic mutations alter ...

A representative figure showing that HELQ-deficient cells fail to undergo normal fork slowing after MMC (a crosslinking agent) treatment, consistent with defective fork reversal. Every time a cell ...