Suppressing CD33 stimulates phagocytosis, slows plaque growth. A protective CD33 mutation could be a gain of function that activates phagocytosis. The CD33 receptor acts as a dimer. At the 14th ...

Microglia tend to get off-kilter in Alzheimer’s and other neurodegenerative diseases. Now, researchers in Tony Wyss-Coray’s lab at Stanford University believe they have discovered a means of restoring ...

Recent studies have found that some cells of the brain, including neurons, astrocytes, and oligodendrocytes, can transport pieces of the genetic code (RNA) from the nucleus out to their distal ...

Parkinson's disease is characterized by the progressive loss of dopaminergic neurons in a specific brain region known as the substantia nigra. This neuronal degeneration is closely linked to ...

Microglia are primary immune cells that safeguard the mammalian brain, partly by devouring or 'phagocytosing' pathogens and toxic debris. Recent genetic studies have consistently highlighted the role ...

Abnormal microglial energy metabolism in AD. Translocation of Aβ into microglial mitochondria by the outer membrane translocase (TOM) impairs mitochondrial function and inhibits phagocytosis. TREM2 ...

Parkinson’s disease (PD) is defined by the progressive loss of dopaminergic neurons in the substantia nigra, but the biological forces that push these neurons toward degeneration remain only partly ...