In a groundbreaking review published in Current Molecular Pharmacology, a team led by Dr. Jhi Biau Foo from Taylor’s University unveils the pivotal role of mutant p53 (mutp53) in driving cancer ...

The transcription factor p53 is the most frequently inactivated tumour suppressor in cancer. Approaches to restore its wild-type function are challenging and have not led to approved drugs. An ...

The tumor suppressor protein p53 plays a critical role in preventing cancer by regulating cell cycle, apoptosis, and genomic stability. However, mutations in the P53 gene are found in over 50% of ...

The utilization of patient-derived organoids as a platform for predicting the efficacy of anti-cancer drugs: Chemotherapy, targeted therapy, and immunotherapy. This is an ASCO Meeting Abstract from ...