A study by IR Sant Pau and CIBERCV identifies for the first time the role of the LRP5 protein in platelet activation and ...

When cancer cells and platelets mix, the risk of metastasis and cancer-related deep vein thrombosis (DVT) and pulmonary embolism (PE) increases, but a small, proof-of-concept study suggests that the ...

Sildenafil is known to reduce cardiac hypertrophy through cGMP-dependent protein kinase (cGK) activation. Studies have demonstrated that cGK has a central switching role in modulating vascular smooth ...

In the course of thrombosis, platelets are exposed to a variety of activating stimuli classified as ‘strong’ (e.g. thrombin and collagen) or ‘mild’ (e.g. ADP). In response, activated platelets adhere ...

Researchers used mouse models and human blood to study LRP5. Inhibition reduced platelet aggregation and arterial thrombosis ...

A recently described hemorrhagic disorder characterized by defective platelet aggregation induced by collagen and epinephrine appears to be caused, in part, by the same abnormality induced by aspirin ...

People who drink diet beverages, chew sugar-free gum, or use low-calorie baking blends may be consuming erythritol every day ...

A new study created a score to identify patients with platelet hyperreactivity and risk of related, future cardiovascular disease. Platelets are circulating cell fragments known to clump up and form ...

Abnormalities of platelet function in some patients with primary, but sporadic, disorders of hemostasis have been attributed to impaired release of platelet adenosine diphosphate (ADP). This defect ...

Platelets are circulating cell fragments known to clump up and form blood clots that stop bleeding in injured vessels. Cardiologists have long known that platelets can become "hyperreactive" to cause ...

Platelets are circulating cell fragments known to clump up and form blood clots that stop bleeding in injured vessels. Cardiologists have long known that platelets can become "hyperreactive" to cause ...