Variant interpretation in cancer susceptibility genes presents unique challenges due to issues such as phenocopies, incomplete/age-related penetrance and the mortality associated with the phenotype.
Molecular oncology laboratories face mounting pressure as expanding sequencing capabilities produce increasingly complex variant profiles that demand extensive interpretation. At the same time, ...
Hearing loss is genetically heterogeneous, with over 121 implicated genes. Minor allele frequency (MAF) data from population databases greatly aid variant interpretation; however, these databases are ...
Circulating tumor DNA (ctDNA) variants hold significant promise as cancer biomarkers in liquid biopsies, owing to their minimally invasive testing approach and capacity to capture the comprehensive ...
Understanding the Biology and Testing Techniques for Pharmacogenomics in Oncology: A Practical Guide for the Clinician Clinical practice guidelines may also provide algorithm-based guidance for use of ...
The XFG variant of the severe acute respiratory syndrome coronavirus 2 as continued to spread as the U.S. heads into peak Summer travel season. (Photo by I RYU/VCG via Getty Images) There’s another ...
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