Abstract. The overexpression of HER3 in solid tumors is associated with poor prognosis. Therapies developed to target HER3-mediated signaling are often associated with resistance over time, ...
Abstract. Regulatory T cells (Tregs) have long been appreciated as a key suppressive cell type that limits anti-tumor immunity, yet it has been challenging to find an effective approach to target this ...
Abstract. The regulation of epithelial (E) and mesenchymal (M) states requires orchestrated adaptation at the epigenomic level. The 3D genome hierarchical orders, together with chromatin accessibility ...
Abstract. Activating mutations in the epidermal growth factor receptor (EGFR) gene occur in 10-20% of Caucasian and 40% of Asian non-small cell lung cancer (NSCLC) patients. Predominant ones among ...
Abstract 2395: DXC011, a novel dual-payload antibody-drug conjugate targeting folate receptor alpha.
Abstract. Folate Receptor alpha (FRα) is highly expressed in epithelial ovarian cancer and selected solid tumors, making it an attractive target for antibody-drug conjugates (ADCs). Although an ...
AbstractBackground:. Urothelial carcinoma (UC) affects over 600,000 patients worldwide annually, with the incidence rate increasing over the past decade. Metastatic urothelial carcinoma (mUC) has a ...
Abstract. Advances in cancer prevention, early detection, and treatment have led to substantial improvements in cancer outcomes in the United States over the past several decades. Despite this ...
Cancer Res (2024) 84 (7_Supplement): ND08. The glycosphingolipid GD2 is a cell membrane component of a limited number of normal tissues including nerve cells, melanocytes or lymphocytes. However, in ...
Abstract. PD-L1 is an established immunotherapy target highly expressed in various solid tumors, while B7-H3 is another extensively investigated target overexpressed on a wide range of tumor cells.
CRISPR screens are a powerful discovery engine for biological research and have been extensively used for drug target discovery and validation. Pooled screens are advantageous because they can easily ...
Abstract. The identification of immunogenic cancer epitopes, including patient-specific neoepitopes and shared tumor-associated antigens (TAAs), is a critical foundation for advancing effective cancer ...
TenSixty Biosciences employs an innovative AI-enhanced multi-omics discovery framework to enable the development of next-generation antibody-drug conjugates (ADCs). This integrated approach identified ...
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