A genome-wide CRISPR-Cas9 screen to identify transcription factor SOX2 as a critical regulator of PROM1, the gene encoding CD133, in glioblastoma stem cells. Knocking out SOX2 reduced CD133 expression ...
Screening ionisable lipids with a gene-editor-sized RNA identified LC-1, an LNP component that retained potency as cargo ...
Sofi-cel is an allogeneic, off-the-shelf, CD7-targeted CAR-T cell therapy being developed for T-cell cancers. Allotera uses ...
A portable CRISPR-Cas13 assay detected mpox virus with 100% sensitivity and specificity in clinical samples from Sierra Leone. The SHINE test identified as few as 10 copies/µL and delivered results in ...
Incyte will share updated clinical single-cell data characterizing its calreticulin-targeted therapy for myeloproliferative ...
Researchers in Germany have identified a SOX9-responsive regulatory route to IRF6, a major orofacial-cleft risk gene, in ...
A mutation-agnostic CRISPR-Cas strategy that inserts a functional rhodopsin coding sequence into the human RHO locus has ...
The first approved CRISPR medicine has now shown similarly strong results in children as young as five years old with sickle cell disease and transfusion-dependent β-thalassaemia. In a pair of phase 3 ...
On 28 January 2026, nChroma Bio dosed the first participant in its Phase 1/2 clinical trial of CRMA-1001, an investigational CRISPR-Cas-based epigenetic silencer targeting chronic hepatitis B virus ...
Researchers have identified how the bacteriophage protein AcrIIA27 inhibits diverse Cas9 enzymes by binding solvent-exposed regions of the guide RNA rather than the protein itself. This structural ...
Wave Life Sciences has reached alignment with the US Food and Drug Administration on a registrational pathway for WVE-006, a GalNAc-conjugated RNA... Rival Editors Converge on AATD as Data Mount Alpha ...
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