Neurodegenerative proteinopathies are characterized by misfolded proteins, which are thought to spread throughout the brain by coaxing healthy proteins to join their filament ranks. Faithful ...
Scientists sorely need biomarkers of TDP-43 pathology, but finding reliable ones has been difficult. Now, two groups, working independently, have proposed a new angle—cryptic circular RNAs, or ...
Ask a clinician or a researcher about the blood-brain barrier (BBB) in Alzheimer’s disease, and you may hear about amyloid or leaky tight junctions. Fibronectin, a major scaffold protein, won’t ...
Shape-shifting cells may explain why APOE4 carriers are at greater risk of cerebrovascular disease. In the 24 September Cell, scientists led by Joel Blanchard at the Icahn School of Medicine at Mount ...
Amyotrophic lateral sclerosis is brutal. Familial mutations cause about one in 10 cases, of which fewer than 1 percent are due to an autosomal-dominant mutation in CHCHD10. Yet one carrier of a ...
During ARIA, immune cells march from blood to brain. What sparks this mobilization? Scientists led by Moustafa Algamal, Mariel Kozberg, and Brian Bacskai at Mass General Brigham investigated this ...
Scientists show off new ways to biochemically probe tiny pieces of brain tissue taken from living people. In the September 24 Nature Communications, Ross Paterson and Aram Aslanyan at University ...
Despite the batch of positive studies, “The current evidence still doesn’t support a protective effect of HRT on dementia risk,” said Kejal Kantarci of the Mayo Clinic in Rochester, Minnesota.
Low dose interleukin 2 is being tested as an immunomodulatory approach in neurodegenerative diseases. It increases the number and activity of regulatory T cells (Tregs) that suppress inflammation. At ...
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