Scientists sorely need biomarkers of TDP-43 pathology, but finding reliable ones has been difficult. Now, two groups, working independently, have proposed a new angle—cryptic circular RNAs, or ...

Neurodegenerative proteinopathies are characterized by misfolded proteins, which are thought to spread throughout the brain by coaxing healthy proteins to join their filament ranks. Faithful ...

The program supports fundamental science and early-stage translational research into sporadic FTD, and awards two-year grants of up to $500,000, inclusive of indirect costs. Early-career and newly ...

Does menopausal hormone therapy raise or lower a woman’s risk of developing dementia? That is a burning question scientists and doctors are trying to answer 23 years after the Women’s Health ...

Lingering for years after an initial injury has healed, chronic neuropathic pain inflicts suffering upon millions around the world. What are the molecular shenanigans that transform a minor injury ...

Shape-shifting cells may explain why APOE4 carriers are at greater risk of cerebrovascular disease. In the 24 September Cell, scientists led by Joel Blanchard at the Icahn School of Medicine at Mount ...

Could a pool of largely overlooked proteins play a crucial role in disease? Growing evidence suggests that human cells make thousands of “microproteins,” i.e., peptides smaller than 150 amino acids, ...

Attention scientists, there is a new tool for your belt—one that untangles which forms of tau crop up in research models and in the human brain. In the 4 September Nature Methods, Kara Juneau, Parag ...

Scientists have created a mouse with a cortex largely made up of human neurons. After deleting most glutamatergic neurons in the mouse neocortex and hippocampus, Sergiu Paşca and colleagues at ...

APOE4 is the strongest genetic risk factor for late-onset Alzheimer’s disease, so why do some carriers live long lives free of dementia? Scientists know that other genetic variants modulate APOE risk.

How to clear pathological proteins that form inside cells is a stubborn challenge for scientists. Derrick Gibbings and colleagues at the University of Ottawa, Ontario, Canada, found a new approach. In ...