Scientists sorely need biomarkers of TDP-43 pathology, but finding reliable ones has been difficult. Now, two groups, working independently, have proposed a new angle—cryptic circular RNAs, or ...
Neurodegenerative proteinopathies are characterized by misfolded proteins, which are thought to spread throughout the brain by coaxing healthy proteins to join their filament ranks. Faithful ...
The program supports fundamental science and early-stage translational research into sporadic FTD, and awards two-year grants of up to $500,000, inclusive of indirect costs. Early-career and newly ...
Shape-shifting cells may explain why APOE4 carriers are at greater risk of cerebrovascular disease. In the 24 September Cell, scientists led by Joel Blanchard at the Icahn School of Medicine at Mount ...
During ARIA, immune cells march from blood to brain. What sparks this mobilization? Scientists led by Moustafa Algamal, Mariel Kozberg, and Brian Bacskai at Mass General Brigham investigated this ...
Does menopausal hormone therapy raise or lower a woman’s risk of developing dementia? That is a burning question scientists and doctors are trying to answer 23 years after the Women’s Health ...
Amyotrophic lateral sclerosis is brutal. Familial mutations cause about one in 10 cases, of which fewer than 1 percent are due to an autosomal-dominant mutation in CHCHD10. Yet one carrier of a ...
Im Neuenheimer Feld 400 69120Heidelberg Germany Visit Website Search Clinics Keywords:Country: Search ...
Could a pool of largely overlooked proteins play a crucial role in disease? Growing evidence suggests that human cells make thousands of “microproteins,” i.e., peptides smaller than 150 amino acids, ...
Scientists have created a mouse with a cortex largely made up of human neurons. After deleting most glutamatergic neurons in the mouse neocortex and hippocampus, Sergiu Paşca and colleagues at ...
APOE4 is the strongest genetic risk factor for late-onset Alzheimer’s disease, so why do some carriers live long lives free of dementia? Scientists know that other genetic variants modulate APOE risk.
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