经历创伤之后，部分痛苦记忆会牢牢刻在脑海中，难以自然淡化，这也是创伤后应激障碍等疾病的重要困扰。小胶质细胞会吞噬突触参与遗忘，但大脑又是如何避免重要记忆被过度清除？ 2026年9月30日，清华大学祁海教授团队在《Neuron》上发表研究“A TMEM119-tankyrase axis restrains microglial phagocytosis to maintain memory and ...
Alzheimer’s disease (AD) involves complex neuroimmune dysregulation, and the role of immune checkpoint pathways in regulating neuro–glial interactions and intrinsic glial homeostasis remains unclear.
In the ever-evolving landscape of neuroscience, new studies continuously unravel the intricate mechanisms that underlie neurological disorders, providing fresh insights and potential therapeutic ...
Parkinson’s disease (PD) is defined by the progressive loss of dopaminergic neurons in the substantia nigra, but the biological forces that push these neurons toward degeneration remain only partly ...
Parkinson's disease is characterized by the progressive loss of dopaminergic neurons in a specific brain region known as the substantia nigra. This neuronal degeneration is closely linked to ...
Summary: Alzheimer’s disease is marked by toxic amyloid-beta protein clumps, but some people seem naturally protected. A new study reveals that a receptor called ADGRG1 enables immune cells called ...
Peripheral nerve injury can lead to allodynia, a pain sensation evoked by innocuous stimuli. A disinhibition of spinal PKCγ interneurons (INs), which receive input from low-threshold mechanoreceptors ...
美国纪念斯隆-凯特琳癌症中心Justin S. A. Perry课题组宣布他们探明了生命早期高果糖损害小胶质细胞吞噬和神经发育。该项研究成果发表在2025年6月11日出版的《自然》上。 在这里，该研究团队 ...
近日，我院神经科学研究所刘军教授团队在中国科学院1区TOP期刊《Cell Death and Differentiation》在线发表研究成果《NLRX1 mediated impaired microglial phagocytosis of NETs in cerebral ischemia and reperfusion injury》。
Following ischemic white matter damage, microglia are responsible for phagocytosing and degrading cholesterol-rich myelin debris, storing them as lipid droplets. However, our understanding of how ...
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