Abstract. Advances in cancer prevention, early detection, and treatment have led to substantial improvements in cancer outcomes in the United States over the past several decades. Despite this ...
AbstractSingle-stranded DNA (ssDNA) gaps represent an underappreciated vulnerability that directly shapes therapeutic response in BRCA-deficient models. Current clinical biomarkers remain anchored to ...
Cancer Discov (2026) 16 (10): OF1.
AbstractSingle-cell RNA sequencing (scRNA-seq) has revolutionized our understanding of cancer. However, identifying meaningful disease states from single-cell data remains challenging due to the ...
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Copyright held by the owner/author(s). This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International ...
AbstractCDK12 mutations occur in 2% to 7% of metastatic prostate cancers (mPCa) and are considered to be exclusively somatic. In this study, we identified five patients with mPCa (ages 44–62) ...
AbstractImmune checkpoint blockade (ICB) has revolutionized cancer treatment, yet its efficacy in gastrointestinal malignancies is often limited by an immunosuppressive tumor microenvironment. In this ...
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